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Water → tert-Butyl 4-(2-methoxy-2-oxoethyl)piperidine-1-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Tert-butyl 4-(2-methoxy-2-oxoethylidene)piperidine-1-carboxylate | HCID 10377658 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | tert-Butyl 4-(2-methoxy-2-oxoethyl)piperidine-1-carboxylate | HCID 1514280 | 99.9% |
反応手順
tert-Butyl 4-(2-methoxy-2-oxoethylidene)piperidine-1-carboxylate (3.6 g, 14 mmol) and 10% Pd/C moistered with water (0.8 g) was mixed in MeOH (75 mL) and stirred under H2 (1 atm) for 4 h. The mixture was filtered through Celite and concentrated to give the title compound (3.6 g, 99%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07427631B2 |
| 出典データセット | uspto-grants-2008_09 |
| ORD ID | ord-48d486ba3dc64acaae68325a2655a90a |
| 出典メモ | uspto-grants-2008_09 |