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HRID 324484作成日：2026年10月24日
Methanol → (+/-)-5-(7-Chloro-1,2-dimethyl-4H-benzo[5,6]cyclohepta[1,2-d]imidazol-4-yl)-1-methyl-2,4(1H,3H)-pyrimidinedione
https://huagongshe.com/ja/reaction/324484
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | Boron trifluoride etherate | HCID 8000 | — |
| 反応物 | 1-Methyluracil | HCID 12009 | — |
| 反応物 | (+/-)-7-Chloro-1,2-dimethyl-4H-benzo[5,6]cyclohepta[1,2-d]imidazol-4-ol | HCID 22003588 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | (+/-)-5-(7-Chloro-1,2-dimethyl-4H-benzo[5,6]cyclohepta[1,2-d]imidazol-4-yl)-1-methyl-2,4(1H,3H)-pyrimidinedione | HCID 22003604 | — |
反応手順
A mixture of the product from step (iii) (0.91 g), and 1-methyluracil (0.44 g) in acetonitrile (40 ml) was treated with boron trifluoride etherate (2.47 g) and heated at 50° C. for 4 h. The solution was treated with methanol (1 ml) and evaporated. Purification was by chromatography on a biotage silica column, using 3% methanol/0.1% 0.880 ammonia in dichloromethane as eluant to give the subtitled product as a cream powder.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US06218376B1 |
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| 出典データセット | uspto-grants-2001_04 |
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| ORD ID | ord-24895a3d2b4044ac8a8aafa6ec8d6d06 |
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| 出典メモ | uspto-grants-2001_04 |
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