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N-(9-Fluorenylmethoxycarbonyloxy)succinimide → n-[(r)-2-[(9h-Fluoren-9-ylmethoxycarbonyl)(1-isopropyl-piperidin-4-ylmethyl)amino]-1-phenylethyl]carbamic acid tert-butyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-(9-Fluorenylmethoxycarbonyloxy)succinimide | HCID 134122 | — |
| 反応物 | N-[(R)-2-[(1-Isopropylpiperidin-4-ylmethyl)amino]-1-phenyl-ethyl]carbamic acid tert-butyl ester | HCID 69307988 | — |
| 生成物 | n-[(r)-2-[(9h-Fluoren-9-ylmethoxycarbonyl)(1-isopropyl-piperidin-4-ylmethyl)amino]-1-phenylethyl]carbamic acid tert-butyl ester | HCID 69309681 | 113.5% |
反応手順
Using coupling method B, N-[(R)-2-[(1-isopropylpiperidin-4-ylmethyl)amino]-1-phenylethyl]carbamic acid tert-butyl ester (1.1 g, 2.8 mmol) and 9-fluorenylmethyl N-succinimidyl carbonate (Fmoc-OSu, 962 mg, 2.9 mmol) afforded 1.9 g of the title compound as a crude residue, that was used without further purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07427632B2 |
| 出典データセット | uspto-grants-2008_09 |
| ORD ID | ord-e4a11d44c2f74fedb928844e4d48c9a0 |
| 出典メモ | uspto-grants-2008_09 |