化工社化工社 化学情報印刷レポート · 研究参考用
4'-Methoxyacetophenone → (S)-1-(4-Methoxyphenyl)ethanol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4'-Methoxyacetophenone | HCID 7476 | — |
| 反応物 | 1-(4-Methoxyphenyl)ethanol | HCID 101148 | — |
| 反応物 | (1R)-1-(4-methoxyphenyl)ethan-1-ol | HCID 641443 | — |
| 生成物 | (S)-1-(4-Methoxyphenyl)ethanol | HCID 6950190 | 48% |
反応手順
As shown here, the biochemical conversion reaction of immobilized green pea protein for the substrate (±)-1-(4-methoxyphenyl)ethanol (200 mg) requires 7 days by going through bioconversion to 4-methoxyacetophenone accompanying sterically selective oxidation of (R)-1-(4-methoxyphenyl)ethanol to obtain 96 mg of (S)-1-(4-methoxyphenyl)ethanol at a yield of 48%. Optical purity was obtained at 95% e.e. Furthermore, HPLC conditions were set at a flow rate of 1.0 ml/min, while GC conditions were set to an oven temperature of 190° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06218581B1 |
| 出典データセット | uspto-grants-2001_04 |
| ORD ID | ord-f42b498c7bc14a1281df39bc764373c6 |
| 出典メモ | uspto-grants-2001_04 |