化工社化工社 化学情報印刷レポート · 研究参考用
Dimethylformamide → 4-Amino-2-[(4-chlorophenoxy)methyl]pteridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | 3-Aminopyrazine-2-carbonitrile | HCID 817699 | — |
| 反応物 | 2-(4-Chlorophenoxy)ethanimidamide | HCID 2735787 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 4-Amino-2-[(4-chlorophenoxy)methyl]pteridine | HCID 10755749 | — |
反応手順
Obtained using the procedure described in section c of Example 2, starting with 10.7 g (0.089 mole) of 3-amino-2-pyrazinecarbonitrile and 24.5 g (0.133 mole) of 2-(4-chlorophenoxy)acetamidine [prepared according to C. Djerassi and C. R. Scholz, U.S. Pat. No. 2,517,468; C.A. 1951, 45, 661f] in 320 ml of absolute ethanol. Refluxing time: 7 hours. Yld: 21.5 g (84%), m.p. 246°-248° C. (N,N-dimethylformamide).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05270465 |
| 出典データセット | uspto-grants-1993_12 |
| ORD ID | ord-80961a04363848518e55b6a7f3125464 |
| 出典メモ | uspto-grants-1993_12 |