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Triethylamine → 5-Chloro-2-(trifluoromethyl)pyrimidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Trifluoroacetamidine | HCID 2776882 | — |
| 反応物 | 2-Chloro-1,3-bis(dimethylamino)trimethinium hexafluorophosphate | HCID 10590807 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 5-Chloro-2-(trifluoromethyl)pyrimidine | HCID 33697960 | — |
反応手順
To a solution of 38 mmol trifluoroacetamidine in 70 ml acetonitrile was added 37.92 mmol ((Z)-2-Chloro-3-dimethylamino-allylidene)-dimethyl-ammonium hexafluoro phosphate (CAS: 291756-76-8) followed by 45.5 mmol triethylamine. The yellow solution was stirred at room temperature for 5 hours, then poured onto water and extracted 3 times with ether. The combined extracts were dried over sodium sulfate, filtered and distilled at 760 mm Hg to provide the title compound. MS (m/e): 182.2 (M+, 100%)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07427612B2 |
| 出典データセット | uspto-grants-2008_09 |
| ORD ID | ord-71874eeb6848488aa5302314746074db |
| 出典メモ | uspto-grants-2008_09 |