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Sodium hydride → 3-isopropyl-3-methyl-3H-imidazo[2,1-a]isoindole-2,5-dione
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | alpha-Isopropyl-alpha-methyl-1,3-dioxo-2-isoindolineacetamide | HCID 4916589 | — |
| 生成物 | 3-isopropyl-3-methyl-3H-imidazo[2,1-a]isoindole-2,5-dione | HCID 2729247 | — |
反応手順
Following the procedure described in Example 1 and sodium hydride as the base, but substituting (-)-α-isopropyl-α-methyl-1,3-dioxo-2-isoindolineacetamide for the racemic compound, the product (+)-3-isopropyl-3-methyl-5H-imidazo[2,1-a] isoindole-2(3H),5-dione is obtained, melting point 137.5°-139° C, [α]D25 +64.54 (THF, C 0.097).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04017510 |
| 出典データセット | uspto-grants-1977_04 |
| ORD ID | ord-823febd55a94474993b1d89135b727cd |
| 出典メモ | uspto-grants-1977_04 |