化工社化工社 化学情報印刷レポート · 研究参考用
1,3-Propanediol → HCID 178520883、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1,3-Propanediol | HCID 10442 | — |
| 反応物 | Sodium | HCID 5360545 | — |
| 反応物 | HCID 178478565 | HCID 178478565 | — |
| 生成物 | HCID 178520883 | HCID 178520883 | — |
反応手順
Sodium (13.5 g.) was added over 3 hours to propane-1,3-diol (450 ml.) under nitrogen at 70° with stirring. This solution was added over 20 minutes to a stirred solution of 4-chloromethylimidazole hydrochloride (50.0 g.) under nitrogen at 40°-60°. Subsequent heating at 60°-65° for 3 hours followed by overnight cooling, filtration and concentration gave 4-(3-hydroxypropoxy)methylimidazole. Subsequent reaction with thionyl chloride gave 4-(3-chloropropoxy)methylimidazole hydrochloride (38.8 g.).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04018931 |
| 出典データセット | uspto-grants-1977_04 |
| ORD ID | ord-5c1ba8c436c741fabf3f82616f0952a1 |
| 出典メモ | uspto-grants-1977_04 |