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Methyl iodide → Ethyl 2-methylacetoacetate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl iodide | HCID 6328 | — |
| 反応物 | Ethyl benzoylacetate | HCID 7170 | — |
| 反応物 | Ethyl Acetoacetate | HCID 8868 | — |
| 反応物 | Ethyl 2-oxocyclopentanecarboxylate | HCID 69136 | — |
| 反応物 | Ethyl 2-methyl-beta-oxobenzenepropanoate | HCID 2760276 | — |
| 生成物 | Ethyl 2-methylacetoacetate | HCID 701 | — |
| 生成物 | Ethyl 1-methyl-2-oxocyclopentane-1-carboxylate | HCID 227353 | — |
| 生成物 | Ethyl 2,2-dimethylbenzoylacetate | HCID 68118422 | — |
反応手順
When the thallous salts of ethyl acetoacetate, 2-carbethoxycyclopentanone, ethyl benzoylacetate, and ethyl 2-methylbenzoylacetate, prepared according to Example 1, are refluxed with methyl iodide as described in Example 1 for periods of about 4, 9, 4, and 14 hours, respectively, ethyl 2-methylacetoacetate (b.p. 82°/25 mm.), 2-methyl-2-carbethoxycyclopentanone (b.p. 124°-126°/35 mm.), ethyl 2-methylbenzoyl acetate (b.p. 96°-97°/0.25 mm.), ), and ethyl 2,2-dimethylbenzoylacetate (b.p. 98°-100°/0.35 mm.), respectively, are obtained in quantitative yield.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04020073 |
| 出典データセット | uspto-grants-1977_04 |
| ORD ID | ord-8ebda59bd5414c03b8ae05616bd75bb4 |
| 出典メモ | uspto-grants-1977_04 |