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N-Piperidinoethanol → HCID 51001939、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-Piperidinoethanol | HCID 18232 | — |
| 反応物 | 2-bromo-6-hydroxy-3-phenyl-1H-inden-1-one | HCID 70306176 | — |
| 反応物 | 3-(3,5-difluorophenyl)-6-hydroxy-2-(pyridin-3-yl)-1H-inden-1-one | HCID 70317432 | — |
| 生成物 | HCID 51001939 | HCID 51001939 | 37% |
反応手順
The procedure of Step 6 of Example 1 was repeated except for using 3-(3,5-difluorophenyl)-6-hydroxy-2-(pyridin-3-yl)-1H-inden-1-one obtained in Step 1 of Example 61 as a starting material instead of 2-bromo-6-hydroxy-3-phenyl-1H-inden-1-one, 2-(piperidin-1-yl)ethanol instead of 4-(2-hydroxyethyl)morpholine, being stirred for 3 h, and being purified by silica gel column chromatography (CH2Cl2/EtOAc=1:4) to obtain the title compound (37%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08877747B2 |
| 出典データセット | uspto-grants-2014_11 |
| ORD ID | ord-b483d7e2622f45bfb5f6653b099626a7 |
| 出典メモ | uspto-grants-2014_11 |