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Pyrrolidine → 4-(Pyrrolidin-1-yl)furan-2(5H)-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pyrrolidine | HCID 31268 | — |
| 反応物 | (+-)-3-Methyl-2,4(3H,5H)-furandione | HCID 544553 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 4-(Pyrrolidin-1-yl)furan-2(5H)-one | HCID 13402454 | — |
反応手順
A mixture of methyl tetronate (2.0 g, 17.5 mmol) and pyrrolidine (4.0 mL, 48 mmol) in EtOH (20 mL) was heated at reflux for 2 hours. The mixture was cooled to room temperature, and evaporated to dryness. The resulting solid was recrystallized with benzene/hexanes to give 4-pyrrolidin-1-ylfuran-2(5H)-one as white crystals. Yield: 2.60 g, 96%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08877923B2 |
| 出典データセット | uspto-grants-2014_11 |
| ORD ID | ord-79d0753606ad4bd99a6b29524ae6c99e |
| 出典メモ | uspto-grants-2014_11 |