関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | 5,5-dimethyl-4-(pyrrolidin-1-yl)furan-2(5H)-one | HCID 25247336 | — |
| 溶媒 | Hydrochloric Acid | HCID 313 | — |
| 生成物 | 4-Hydroxy-5,5-dimethyl-2(5H)-furanone | HCID 54720139 | — |
反応手順
A suspension of 5,5-dimethyl-4-pyrrolidin-1-ylfuran-2(5H)-one (535 mg) in a mixture of MeOH (2 mL) and 5M HCl (8 mL) was heated at 88° C. for 2 hours. The mixture was cooled to room temp., extracted with CHCl3 (10×15 mL), combined, dried over Na2SO4, and evaporated to dryness to give 4-hydroxy-5,5-dimethyl-5H-furan-2-one as light brown solid. Yield: 359 mg, 95%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08877923B2 |
|---|
| 出典データセット | uspto-grants-2014_11 |
|---|
| ORD ID | ord-6057f08f280d40e299280dbdc5fb3106 |
|---|
| 出典メモ | uspto-grants-2014_11 |
|---|
