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Dimethylformamide → 5-Bromo-3-(3-methoxyphenylthio)picolinonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 3-Methoxybenzenethiol | HCID 84989 | — |
| 反応物 | 5-Bromo-3-nitropyridine-2-carbonitrile | HCID 2769698 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 5-Bromo-3-(3-methoxyphenylthio)picolinonitrile | HCID 66994755 | 82% |
反応手順
A 10 mL round-bottomed flask was charged with 5-bromo-3-nitropicolinonitrile (300 mg, 1.31 mmol), 3-methoxybenzenethiol (0.150 mL, 1.31 mmol), and DMF (12 mL). NaH (37.8 mg, 1.58 mmol) was added and reaction stirred at room temperature for 10 minutes. The reaction was poured into water and extracted with EtOAc. The organic layer was dried over sodium sulfate, filtered and concentrated. The resulting residue was purified on silica gel (10% EtOAc in Hexanes) to afford the title compound (345 mg, 81%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08883828B2 |
| 出典データセット | uspto-grants-2014_11 |
| ORD ID | ord-42fbcbf997444d6dadb900bddb096fd9 |
| 出典メモ | uspto-grants-2014_11 |