化工社化工社 化学情報印刷レポート · 研究参考用
3-[(7-Bromo-imidazo[1,2-a]pyridine-3-carbonyl)-amino]-4-fluorobenzoic acid → (S)-7-Bromo-N-(5-((5,5-dimethyltetrahydrofuran-2-yl)methylcarbamoyl)-2-fluorophenyl)imidazo[1,2-a]pyridine-3-carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-[(7-Bromo-imidazo[1,2-a]pyridine-3-carbonyl)-amino]-4-fluorobenzoic acid | HCID 71283443 | — |
| 反応物 | (R)-(5,5-dimethyltetrahydrofuran-2-yl)methanaminium chloride | HCID 86695690 | — |
| 生成物 | (S)-7-Bromo-N-(5-((5,5-dimethyltetrahydrofuran-2-yl)methylcarbamoyl)-2-fluorophenyl)imidazo[1,2-a]pyridine-3-carboxamide | HCID 71282935 | — |
反応手順
The title compound was prepared from (R)-(5,5-dimethyltetrahydrofuran-2-yl)methanaminium chloride (Intermediate 9B) and 3-(7-Bromoimidazo[1,2-a]pyridine-3-carboxamido)-4-fluoro benzoic acid (prepared by hydrolysis of methyl 3-(7-bromoimidazo[1,2-a]pyridine-3-carboxamido)-4-fluorobenzoate (Intermediate 1A) using NaOH) analogously to Example 7.4 step 1;
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08883819B2 |
| 出典データセット | uspto-grants-2014_11 |
| ORD ID | ord-fe25fa673bbe401ca95296ba172be2a0 |
| 出典メモ | uspto-grants-2014_11 |