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HRID 336178作成日：2026年10月24日
Hydrochloric Acid → 3'-Chloro-5'-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-3-carboxylic acid (5-tert-butyl-isoxazol-3-yl)-amide
https://huagongshe.com/ja/reaction/336178
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine | HCID 1268075 | — |
| 反応物 | HCID 58563805 | HCID 58563805 | — |
| 溶媒 | tert-Butanol | HCID 6386 | — |
| 生成物 | 3'-Chloro-5'-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-3-carboxylic acid (5-tert-butyl-isoxazol-3-yl)-amide | HCID 46872043 | — |
反応手順
A microwave reaction vial is charged with piperidine-3-carboxylic acid (5-tert-butyl-isoxazol-3-yl)-amide; hydrochloride (94 mg; 0.327 mmol), 3-chloro-2-fluoro-5-trifluoromethylpyridine (0.043 mL; 0.33 mmol), triethylamine (0.092 mL; 0.66 mmol) and t-butanol (0.5 mL). The vial is heated in microwave at 175° C. for 1 hour then left standing at room temperature overnight. The reaction mixture is concentrated in vacuo. Purification by flash chromatography on silica using methanol/methylene chloride then recrystallization from hot methanol provides the title compound, m/z 431 [M+H+].
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US08889670B2 |
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| 出典データセット | uspto-grants-2014_11 |
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| ORD ID | ord-b7d621c0d7a44d1389355d608ad1b156 |
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| 出典メモ | uspto-grants-2014_11 |
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