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1-Benzyl-2-ethyl-4-methoxy-1H-indole → 1-Benzyl-2-ethyl-1H-indol-4-OL
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Benzyl-2-ethyl-4-methoxy-1H-indole | HCID 9943241 | — |
| 反応物 | Boron tribromide dichloromethane | HCID 22277759 | — |
| 生成物 | 1-Benzyl-2-ethyl-1H-indol-4-OL | HCID 9816416 | 54% |
反応手順
By the method used in Example 1, Part D, 3.1 g 11.7 mmol of 2ethyl-4-methoxy-1-(phenylmethyl)-1H-indole was O-demethylated by treating it with 48.6 mL of 1M BBr3 /CH2Cl2 to give a material that was chromatographed on silica gel (eluted with 20% EtOAc/hexane) to give 1.58 g (54% yield) of 2-ethyl-4-hydroxy-1-(phenylmethyl)-1H-indole, mp, 86°-90° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05733923 |
| 出典データセット | uspto-grants-1998_03 |
| ORD ID | ord-a407b211fca84e1ca3a7311663e629e3 |
| 出典メモ | uspto-grants-1998_03 |