化工社化工社 化学情報印刷レポート · 研究参考用
N-(3-Chloropropyl)dibutylamine → (2-Butyl-5-nitrobenzofuran-3-yl)(4-(3-dibutylaminopropoxy)phenyl)methanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-(3-Chloropropyl)dibutylamine | HCID 96084 | — |
| 反応物 | Aluminum(III) Chloride | HCID 6451240 | — |
| 反応物 | (2-Butyl-5-nitro-1-benzofuran-3-yl)(4-hydroxyphenyl)methanone | HCID 11473234 | — |
| 反応物 | (2-Butyl-5-nitrobenzofuran-3-yl)(4-methoxyphenyl)methanone | HCID 22595055 | — |
| 生成物 | (2-Butyl-5-nitrobenzofuran-3-yl)(4-(3-dibutylaminopropoxy)phenyl)methanone | HCID 10209258 | — |
反応手順
Industrial application of this last reaction step involves difficulties, because 2-n-butyl-3-(4-methoxybenzoyl)-5-nitro-benzofuran (X) is mutagenic, and aluminum chloride is harmful for the health. The resulting 2-n-butyl-3-(4-hydroxybenzoyl)-5-nitro-benzofuran (XI) on reaction with dibutylamino-propylchloride furnishes 2-n-butyl-3-[4-(3-dibutylamino-propoxy)benzoyl]-5-nitro-benzofuran (XII)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08889734B2 |
| 出典データセット | uspto-grants-2014_11 |
| ORD ID | ord-87423c71517d47aebd9d59b5b6610db8 |
| 出典メモ | uspto-grants-2014_11 |