Isobutyl iodide → 2-[4-(1-Isobutyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline

HRID 33862

反応式

HRID 33862 の反応式
C([N:4]1[CH:8]=[C:7]([C:9]2[CH:14]=[CH:13][N:12]=[CH:11][CH:10]=2)[C:6]([C:15]2[CH:32]=[CH:31][C:18]([O:19][CH2:20][C:21]3[CH:30]=[CH:29][C:28]4[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=4)[N:22]=3)=[CH:17][CH:16]=2)=[N:5]1)(C)C.I[CH2:34][CH:35]([CH3:37])[CH3:36]>>[CH2:34]([N:4]1[CH:8]=[C:7]([C:9]2[CH:14]=[CH:13][N:12]=[CH:11][CH:10]=2)[C:6]([C:15]2[CH:32]=[CH:31][C:18]([O:19][CH2:20][C:21]3[CH:30]=[CH:29][C:28]4[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=4)[N:22]=3)=[CH:17][CH:16]=2)=[N:5]1)[CH:35]([CH3:37])[CH3:36]

参加物

3

反応物 2

HCID 10556Isobutyl iodideHCID 115318622-[4-(1-Isopropyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline

生成物 1

HCID 116620242-[4-(1-Isobutyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline

実験手順

Following the procedure for the preparation of 2-[4-(1-Isopropyl-4-pyridin4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline but substituting 1-Iodo-2-methyl-propane provided the title compound. 1H NMR (400 MHz, CDCl3) δ 8.44 (m, 2H), 8.18 (d, J=8.7 Hz, 1H), 8.06 (d, J=8.3 Hz, 1 H), 7.83 (d, J=6.6 Hz, 1 H), 7.73 (t, J=6.6 Hz, 1H), 7.54 (s,1H), 7.52 (m, 1H), 7.38 (d, J=9.1 Hz, 2 H), 7.15 (m, 2H), 7.00 (d, J=8.7 Hz, 2 H), 5.38 (s, 2H) 3.93 (d, J=7.5 Hz, 2 H), 4.29 (m, 1H), 0.95 (d, J=6.6 Hz, 6H); MS: (M+H m/z=435.2).

出典と根拠

ORDレコード
ord-a1c5095a5e5a41e0b1f8d018bbe52289
出典データセット
uspto-grants-2008_09
特許番号
US07429665B2

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