関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Formamide | HCID 713 | — |
| 反応物 | p-Toluenesulfinic acid | HCID 10818 | — |
| 反応物 | Benzaldehyde, 4-(phenylmethoxy)- | HCID 78109 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | N-((4-(Benzyloxy)phenyl)(tosyl)methyl)formamide | HCID 59797510 | 49% |
反応手順
A mixture of 4-methylbenzenesulfinic acid (3.1 g, 19.9 mmol), 4-(benzyloxy)benzaldehyde (4.2 g, 19.9 mmol), and formamide (4.5 mL ) was heated at 60° C. for 20 h. The mixture was diluted with methanol and stirring was continued for 1 h at rt. The resultant solid was filtered and dried to give 3.81 g (49%) of a white solid. The product was used in the next step without future purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07429665B2 |
|---|
| 出典データセット | uspto-grants-2008_09 |
|---|
| ORD ID | ord-89e71a12bdda428480b51ec0550a9332 |
|---|
| 出典メモ | uspto-grants-2008_09 |
|---|
