関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Ammonium formate | HCID 2723923 | — |
| 反応物 | 4-(4-(4-(Benzyloxy)phenyl)oxazol-5-yl)pyridine | HCID 59797495 | — |
| 触媒 | Palladium hydroxide | HCID 9942167 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 4-(5-(Pyridin-4-yl)oxazol-4-yl)phenol | HCID 135988007 | 96% |
反応手順
To a solution of 4-(4-(4-(Benzyloxy)phenyl)oxazol-5-yl)pyridine (300 g, 0.91 mmol) was added 20% Pd(OH)2/C (30 mg) and ammonium formate (115 mg, 1.83 mmol) in methanol (8 mL ). The solution was heated at 60° C. for 20 min. The catalyst was removed by filtration and the filtrate was concentrated to give 208 mg (96%) of the title compound. 1H NMR (400 MHz, CDCl3) δ: 6.92 (m, 2H), 7.46 (m, 2H), 7.57 (d, 2H), 8.02 (s, 1H), 8.58 (m, 2H). MS m/z: 239 [M+1]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07429665B2 |
|---|
| 出典データセット | uspto-grants-2008_09 |
|---|
| ORD ID | ord-ae39e9b2b2d24b949af664716859a5e8 |
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| 出典メモ | uspto-grants-2008_09 |
|---|
