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4-(6-Methoxy-1,3-benzothiazol-2-yl)aniline → 3-Trifluoromethyl-N-[4-(6-methoxy-1,3-benzothiazol-2-yl)phenyl]-4-(methoxy)benzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-(6-Methoxy-1,3-benzothiazol-2-yl)aniline | HCID 391870 | — |
| 反応物 | 4-Methoxy-3-(trifluoromethyl)benzoyl chloride | HCID 2775298 | — |
| 溶媒 | Pyridine | HCID 1049 | — |
| 生成物 | 3-Trifluoromethyl-N-[4-(6-methoxy-1,3-benzothiazol-2-yl)phenyl]-4-(methoxy)benzamide | HCID 67313154 | 87% |
反応手順
Prepared as described in the Amide Coupling section using 2-(4-aminophenyl)-6-methoxybenzothiazole (0.5 g, 1.95 mmol) and 4-methoxy-3-trifluoromethylbenzoyl chloride (0.47 g, 1.95 mmol) in dry pyridine (15 ml) to give the title compound (0.77 g, 87%) as pale yellow feathery crystals after work-up and recrystallisation from acetic acid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08895313B2 |
| 出典データセット | uspto-grants-2014_11 |
| ORD ID | ord-f231a315b48e409ca85777f2f217b6a9 |
| 出典メモ | uspto-grants-2014_11 |