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Triethylamine → 4-Chloro-2,6-dimethyl-5-{[4-(trifluoromethyl)phenyl]ethynyl}pyrimidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Phosphorus oxychloride | HCID 24813 | — |
| 反応物 | 1-Ethynyl-4-(trifluoromethyl)benzene | HCID 4348295 | — |
| 反応物 | 5-Iodo-2,6-dimethylpyrimidin-4-ol | HCID 135447935 | — |
| 触媒 | HCID 178418476 | HCID 178418476 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 4-Chloro-2,6-dimethyl-5-{[4-(trifluoromethyl)phenyl]ethynyl}pyrimidine | HCID 86660706 | — |
反応手順
2,6-Dimethyl-5-iodo-4(3H)-pyrimidinone and 4-ethynyl-α,α,α-trifluorotoluene were reacted in toluene in the presence of dichlorobis(triphenylphosphine)palladium, cuprous iodide, and triethylamine while stirring under room temperature to heating to obtain a compound. The compound was mixed with POCl3 and reacted while heating under reflux to obtain a target substance. The target substance was subjected to e.g., proton nuclear magnetic resonance spectrometry (1H-NMR) and mass spectrometry (MS) and confirmed as the titled compound. Furthermore, MS measurement result is shown.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08895565B2 |
| 出典データセット | uspto-grants-2014_11 |
| ORD ID | ord-821eedf0fb894a2ba9087b8285f1b445 |
| 出典メモ | uspto-grants-2014_11 |