化工社化工社 化学情報印刷レポート · 研究参考用
(3R)-(+)-3-(Dimethylamino)pyrrolidine → HCID 178436921、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (3R)-(+)-3-(Dimethylamino)pyrrolidine | HCID 2758521 | — |
| 反応物 | HCID 178436919 | HCID 178436919 | — |
| 生成物 | HCID 178436921 | HCID 178436921 | 38.2% |
反応手順
The title compound was prepared from (5-chloropyrazin-2-yl)(2-(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)methanone (80 mg, 154 μmol) and (R)-3-dimethylaminopyrrolidine, (35 mg, 308 μmol) using the method of Example 32. The crude material was purified by HPLC Method C to afford (35 mg, 38%) of the title compound as white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08895544B2 |
| 出典データセット | uspto-grants-2014_11 |
| ORD ID | ord-55af3cd62afc4085b7a12114e78b59ad |
| 出典メモ | uspto-grants-2014_11 |