関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 3-Bromopyridine | HCID 12286 | — |
| 反応物 | Phosphine, tris(4-methylphenyl)- | HCID 13956 | — |
| 反応物 | 3-vinyl-4-methoxy-1-trityl-1H-indazole-5-carbonitrile | HCID 23070127 | — |
| 触媒 | palladium(II) acetate | HCID 167845 | — |
| 溶媒 | Triethylamine | HCID 8471 | — |
| 生成物 | 4-Methoxy-3-[(E)-2-(pyridin-3-yl)-vinyl]-1-trityl-1H-indazole-5-carbonitrile | HCID 68928542 | — |
反応手順
300 mg of 3-vinyl-4-methoxy-1-trityl-1H-indazole-5-carbonitrile and 180 μl of 3-bromopyridine were dissolved in a mixed solvent of 1 mL triethylamine/5 mL acetonitrile, added with 40 mg of tri-p-tolylphosphine and 27 mg of palladium acetate (II), and heated at 110° C. for 24 hours. The reaction solution was added with silica gel, the solvent was evaporated, and the resultant residue was purified by column chromatography (hexane:ethyl acetate=7:3), to afford 120 mg of the title compound as a pale yellow oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US07429609B2 |
|---|
| 出典データセット | uspto-grants-2008_09 |
|---|
| ORD ID | ord-4110f144624145549fb126ad24035122 |
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| 出典メモ | uspto-grants-2008_09 |
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