関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 6-Acetylamino-2-methyl-3-nitro-benzoic acid | HCID 15283171 | — |
| 溶媒 | Sodium Hydroxide | HCID 14798 | — |
| 生成物 | 6-Amino-2-methyl-3-nitrobenzoic acid | HCID 15283172 | — |
反応手順
450 ml of 2N NaOH are initially taken and 75.6 g (0.317 mol) of 2-methyl-3-nitro-6-acetamidobenzoic acid are added. The reaction mixture is then warmed to 95° C. and is stirred at this temperature for one hour. After cooling to 10° C., it is acidified by addition of 425 ml of 2N HCl, and the precipitate which deposits is filtered off with suction, washed with water and dried under reduced pressure at 50° C. Yield: 50.7 g (0.258 mol)=82% of theory, m.p.: 183°-184° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05863864 |
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| 出典データセット | uspto-grants-1999_01 |
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| ORD ID | ord-e142719f3f5846c98226c035ba74df6b |
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| 出典メモ | uspto-grants-1999_01 |
|---|
