化工社化工社 化学情報印刷レポート · 研究参考用
Hydrochloric Acid → Methyl 3-amino-2-chloro-5-fluoro-4-methylbenzoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | Sodium Carbonate | HCID 10340 | — |
| 反応物 | 3-Amino-2-chloro-5-fluoro-4-methylbenzoic acid | HCID 13657440 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | Methyl 3-amino-2-chloro-5-fluoro-4-methylbenzoate | HCID 13657452 | — |
反応手順
12 g of 3-amino-2-chloro-5-fluoro-4-methylbenzoic acid are initially introduced into 60 ml of MeOH. HCl gas is passed in for 20 minutes and is then boiled under reflux for 5 hours. Thereafter, the mixture is poured into water and rendered alkaline with sodium carbonate and the product is isolated. Yield: 8 g, melting point: 51°-52°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04762844 |
| 出典データセット | uspto-grants-1988_08 |
| ORD ID | ord-be8a1afed337406c888ecd39e8cf4276 |
| 出典メモ | uspto-grants-1988_08 |