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Tetrahydrofuran → 2-(Ethyl(1-ethynylcyclohexyl)amino)ethan-1-ol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Tetrahydrofuran | HCID 8028 | — |
| 反応物 | Cyclohexanol, 1-ethynyl-, 1-acetate | HCID 78903 | — |
| 反応物 | Ethylaminoethanol | HCID 18179409 | — |
| 触媒 | Cuprous chloride | HCID 62652 | — |
| 生成物 | 2-(Ethyl(1-ethynylcyclohexyl)amino)ethan-1-ol | HCID 22314189 | — |
反応手順
To 1.17 ml (12 mmo) ethylaminoethanol in 8 ml THF were added 29.8 mg (0.3 mmol) CuCl, followed by 1 g (6.02 mmol) 1-ethynylcyclohexyl acetate. The solution was stirred at RT for 3 h, the solvent was removed and the residue dissolved in ether/2M HCl. The phases were separated, and after addition of NaOH (pH11) to the aqueous phase, it was extracted with ether. The ether phase was dried over Na2SO4 and concentrated. Distillation by Kugelrohr yielded 2-[Ethyl-(1-ethynyl-cyclohexyl)-amino]-ethanol as colorless oil, MS: 196 (MH+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07173043B2 |
| 出典データセット | uspto-grants-2007_02 |
| ORD ID | ord-812a42b562b4483992146eccdf850e9a |
| 出典メモ | uspto-grants-2007_02 |