化工社化工社 化学情報印刷レポート · 研究参考用
1,1,1-Trifluoro-2-isothiocyanatoethane → 4-[3-(2,2,2-Trifluoroethyl)thioureido]-2-(4-phthalimidobutyl)pyrimidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1,1,1-Trifluoro-2-isothiocyanatoethane | HCID 13883777 | — |
| 反応物 | 4-Amino-2-(4-phthalimidobutyl)pyrimidine | HCID 20450337 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 4-[3-(2,2,2-Trifluoroethyl)thioureido]-2-(4-phthalimidobutyl)pyrimidine | HCID 54214531 | 69.8% |
反応手順
A mixture of 4-amino-2-(4-phthalimidobutyl)pyrimidine (1 g.), 2,2,2-trifluoroethylisothiocyanate (1 g.) and acetonitrile was stirred at 70° for 18 hours. The mixture was diluted with acetonitrile (10 ml.), cooled in ice and then filtered to give 4-[3-(2,2,2-trifluoroethyl)thioureido]-2-(4-phthalimidobutyl)pyrimidine (1.03 g.), m.p. 204°-205°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04762932 |
| 出典データセット | uspto-grants-1988_08 |
| ORD ID | ord-ca82245d01c64c8aa746d59c200086f1 |
| 出典メモ | uspto-grants-1988_08 |