化工社化工社 化学情報印刷レポート · 研究参考用
2,3,4,5-tetrahydro-1H-1-benzazepine → 1-(4-Cyano-2-methylbenzoyl)-2,3,4,5-tetrahydro-1H-1-benzazepine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2,3,4,5-tetrahydro-1H-1-benzazepine | HCID 576503 | — |
| 反応物 | 4-Cyano-2-methylbenzoic acid | HCID 11819339 | — |
| 生成物 | 1-(4-Cyano-2-methylbenzoyl)-2,3,4,5-tetrahydro-1H-1-benzazepine | HCID 21083237 | — |
反応手順
The carboxylic acid from Example D (0.96 g, 5.95 mmol) was reacted with 2,3,4,5-tetrahydro-1H-1-benzazepine (0.80 g, 5.44 mmol) according to the procedure in Example 1A. The product was purified by flash chromatography on silica (eluant EtOAc:pet. ether 30:70); yield 0.59 g (38%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07176195B2 |
| 出典データセット | uspto-grants-2007_02 |
| ORD ID | ord-b06e9397f68f49559e1e2e78bfa0ac13 |
| 出典メモ | uspto-grants-2007_02 |