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1,1,1-Trifluoro-2-isothiocyanatoethane → 4-[3-(2,2,2-Trifluoroethyl)thioureido]-2-[(2-phthalimidoethyl)thiomethyl]pyrimidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1,1,1-Trifluoro-2-isothiocyanatoethane | HCID 13883777 | — |
| 反応物 | 4-Amino-2-[(2-phthalimidoethyl)thiomethyl)pyrimidine | HCID 21298818 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 4-[3-(2,2,2-Trifluoroethyl)thioureido]-2-[(2-phthalimidoethyl)thiomethyl]pyrimidine | HCID 53848275 | 62.6% |
反応手順
A mixture of 4-amino-2-[(2-phthalimidoethyl)thiomethyl]pyrimidine (5.9 g.), 2,2,2-trifluoroethylisothiocyanate (3.9 g.) and acetonitrile (20 ml.) was stirred at 70° for 72 hours. The reaction mixture was cooled and the crystalline precipitate collected to give 4-[3-(2,2,2-trifluoroethyl)thioureido]-2-[(2-phthalimidoethyl)thiomethyl]pyrimidine (5.35 g.), m.p. 178°-179°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04762932 |
| 出典データセット | uspto-grants-1988_08 |
| ORD ID | ord-1167a016d84a432a991c34ad0be5e4e8 |
| 出典メモ | uspto-grants-1988_08 |