関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Acetic Anhydride | HCID 7918 | — |
| 反応物 | Hydrazine hydrate (1:1) | HCID 24654 | — |
| 反応物 | Acetic acid, (p-aminobenzoyl)-, ethyl ester (6CI,7CI) | HCID 3045879 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 3-(4-Acetylaminophenyl)-2-pyrazolin-5-one | HCID 13879144 | — |
反応手順
In 440 ml of acetonitrile was dissolved 146 g of ethyl p-aminobenzoylacetate, and 70 ml of acetic anhydride was added dropwise to the solution at 40° C. After reacting at 40° C. for 1 hour, 48.8 g of 80% hydrazine hydrate was added thereto dropwise. After heat generation subsided, the reaction was further continued at a temperature between 55° C. and 60° C. for 1 hour. The reaction mixture was cooled to 5° C., and the precipitated crystals were filtered to yield 148 g of 3-(4-acetylaminophenyl)-2-pyrazolin-5-one as gray crystals having a melting point of 254° to 258° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04764458 |
|---|
| 出典データセット | uspto-grants-1988_08 |
|---|
| ORD ID | ord-08d6d7f94b4f4cc897e7e0b7b69e8795 |
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| 出典メモ | uspto-grants-1988_08 |
|---|
