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Triethylamine → 3-(5,6,7,8-Tetrahydroquinol-8-yl)propylamino-3-nitro-5-(pyrid-3-ylmethyl)pyridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 3-(5,6,7,8-Tetrahydroquinol-8-yl)propylamine | HCID 19851779 | — |
| 反応物 | 2-Chloro-3-nitro-5-(pyrid-3-ylmethyl)pyridine hydrochloride | HCID 19851787 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 3-(5,6,7,8-Tetrahydroquinol-8-yl)propylamino-3-nitro-5-(pyrid-3-ylmethyl)pyridine | HCID 19851797 | 86.5% |
反応手順
A mixture of 3-(5,6,7,8-tetrahydroquinol-8-yl)propylamine (4.5 g), 2-chloro-3-nitro-5-(pyrid-3-ylmethyl)pyridine hydrochloride (5 g) and triethylamine (10 ml) was refluxed in ethanol (200 ml) for 7.5 hours. The solvent was removed in vacuo, the residue was dissolved in chloroform and chromatographed on silica in chloroform and later chloroform/methanol 4:1. The fractions containing the product were concentrated to give the title compound as an oil (6.1 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04764519 |
| 出典データセット | uspto-grants-1988_08 |
| ORD ID | ord-4bfa4c33e2054304a26c369a1db80481 |
| 出典メモ | uspto-grants-1988_08 |