化工社化工社 化学情報印刷レポート · 研究参考用
Potassium Carbonate → Codeine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Morphine | HCID 5288826 | — |
| 触媒 | Phenyltrimethylammonium chloride | HCID 67309 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | Codeine | HCID 5284371 | 99% |
反応手順
Morphine of purity 35% 815 parts (1 mole parts), potassium carbonate 552 parts (4 moles part) and trimethylphenyl-ammonium chloride 188 parts (1.1 moles part) are heated under stirring in toluene (5000 parts) at 45° to 120° C. for 2 to 5 hrs. to yield 296 parts codeine (99% yield), after workup as in Example 1.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04764615 |
| 出典データセット | uspto-grants-1988_08 |
| ORD ID | ord-c1e947f17ce243b68b89f16f82f29d57 |
| 出典メモ | uspto-grants-1988_08 |