化工社化工社 化学情報印刷レポート · 研究参考用
Sodium Hydroxide → Regadenoson Impurity 1
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Ethyl 1-(6-amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-2-yl)-1H-pyrazole-4-carboxylate | HCID 9865974 | — |
| 生成物 | Regadenoson Impurity 1 | HCID 9864495 | — |
反応手順
Compound 12 (0.05 mg, 0.12 mmol) was dissolved one equivalent of 1N NaOH. The solution was allowed to stir at Rt for 2 h, then acidified to pH 4. The resulting precipitate was filtered and washed with water and ether. 1HNMR (CD3OD) Δ3.75 (m, 1 H), 3.90 (m, 1 H), 4.13 (d, 1 H), 4.43 (d, 1 H), 4.64 (m, 1 H), 6.05 (d, 1 H), 8.10 (s, 1 H), 8.35 (s, 1 H), 9.05 (s, 1 H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07183264B2 |
| 出典データセット | uspto-grants-2007_02 |
| ORD ID | ord-e13eba1afced4d90b5575e9a350914c4 |
| 出典メモ | uspto-grants-2007_02 |