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4-Acetamidobenzaldehyde → 2-Ethylhexyl 3-(4-acetylaminophenyl)-2-cyanoacrylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Acetamidobenzaldehyde | HCID 73942 | — |
| 反応物 | 2-Ethylhexyl cyanoacetate | HCID 96359 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 生成物 | 2-Ethylhexyl 3-(4-acetylaminophenyl)-2-cyanoacrylate | HCID 69201897 | 54% |
反応手順
A mixture of 35 g (0.18 mol) of 2-ethylhexyl cyanoacetate and 30 g (0.18 mol) of 4-acetamidobenzaldehyde in 300 ml of isopropanol is refluxed for 3 hours. The reaction mixture is then allowed to cool and is crystallized. The crystals formed are separated out by filtration and are recrystallized from a minimum amount of isopropanol. After filtration and drying, 33.3 g (54% yield) of 2-ethylhexyl 3-(4-acetylaminophenyl)-2-cyanoacrylate are obtained in the form of a pale yellow powder.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06749839B2 |
| 出典データセット | uspto-grants-2004_06 |
| ORD ID | ord-6cb71ca2a1374163a3fe5991ff5e5074 |
| 出典メモ | uspto-grants-2004_06 |