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1,4-Cyclohexadiene → 1-Aminocyclopropylcarboxylic acid 2,2,5,5-tetramethylcyclopentyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1,4-Cyclohexadiene | HCID 12343 | — |
| 反応物 | N-Cbz-1-aminocyclopropanecarboxylic acid 2,2,5,5-tetramethylcyclopentyl ester | HCID 53791828 | — |
| 反応物 | HCID 178418361 | HCID 178418361 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 生成物 | 1-Aminocyclopropylcarboxylic acid 2,2,5,5-tetramethylcyclopentyl ester | HCID 17992581 | — |
反応手順
N-Cbz-1-aminocyclopropanecarboxylic acid 2,2,5,5-tetramethylcyclopentyl ester is dissolved in absolute alcohol at 0° C. in an ultrasound bath. Palladium on carbon (10%) is added. The hydrogen source, 1,4-cyclohexadiene, is added, and ultrasound is commenced for eight minutes. The slurry is then filtered through a bed of Celite with ethyl alcohol. The solvent is removed by rotary evaporation to yield 1-aminocyclopropylcarboxylic acid 2,2,5,5-tetramethylcyclopentyl ester.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04766246 |
| 出典データセット | uspto-grants-1988_08 |
| ORD ID | ord-53af94323f0249e79cb917e1a1115caf |
| 出典メモ | uspto-grants-1988_08 |