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Hydrochloric Acid → methyl 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Methyl chloroacetate | HCID 7295 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 2-methyl-1,2-benzisothiazol-3(2H)-one 1,1-dioxide | HCID 27290 | — |
| 溶媒 | Dimethyl Sulfoxide | HCID 679 | — |
| 生成物 | methyl 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide | HCID 54676532 | — |
反応手順
In a manner similar to Example 6, 864 mg. (0.036 mole) of 99% sodium hydride was added over a two hour period to a solution of 2.9 g. (0.015 mole) of N-methylsaccharin and 9.8 g. (0.09 mole) of methylchloroacetate in 10 ml. of dimethylsulfoxide at 40° C. Stirring was continued at 40°-45° C. for an additional two hours, and the reaction mixture was poured into 150 ml. of 5% hydrochloric acid solution. The precipitate was filtered and dried to give 3.07 (76%) of the desired product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04376204 |
| 出典データセット | uspto-grants-1983_03 |
| ORD ID | ord-9865dd9ec9a04768ba0cef810bfeaf60 |
| 出典メモ | uspto-grants-1983_03 |