関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 6-Bromohexanenitrile | HCID 81093 | — |
| 反応物 | 1-(3-Hydroxybenzyl)piperidine | HCID 826974 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | 6-(3-Piperidinomethylphenoxy)hexanenitrile | HCID 21294599 | — |
反応手順
N-(3-Hydroxybenzyl)piperidine (9.55 g) was heated with 6-bromohexanenitrile (10.2 g) and potassium carbonate (13.8 g) under reflux in acetone (150 ml) for 66 hours. The reaction mixture was cooled and filtered. The solvent was removed by evaporation and the residue was heated with stirring at 100° C. for one hour to remove unreacted 6-bromohexanenitrile and to yield 6-(3-piperidinomethylphenoxy)hexanenitrile as an oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04767769 |
|---|
| 出典データセット | uspto-grants-1988_08 |
|---|
| ORD ID | ord-7da3d269d1874f798df02cc7c96fa40f |
|---|
| 出典メモ | uspto-grants-1988_08 |
|---|
