関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 3-Chloropropionitrile | HCID 10963 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 2-(3-Piperidinomethylbenzyl)isothiourea dihydrochloride | HCID 21294508 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 3-(3-Piperidinomethylbenzylthio)propionitrile | HCID 21294535 | — |
反応手順
A stirred solution of the above isothiourea (1.2 g) and 3-chloropropionitrile (0.4 ml) in a mixture of water (7 ml) and ethanol (5 ml) was treated at 0°-5° C. with 2.5N sodium hydroxide (5.3 ml). The reaction mixture was stirred at 0°-5° C. for a further hour and then allowed to warm to 20° C. The reaction mixture was extracted with ethyl acetate and the extracts washed with water, dried and evaporated to provide 3-(3-piperidinomethylbenzylthio)propionitrile as an oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04767769 |
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| 出典データセット | uspto-grants-1988_08 |
|---|
| ORD ID | ord-32d906c82aa74fe0909bac945dd9dd2c |
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| 出典メモ | uspto-grants-1988_08 |
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