化工社化工社 化学情報印刷レポート · 研究参考用
N-Methylhydrazinecarbothioamide → N-Methyl-N-[3-[3-(methylamino)-1,2,4-triazolo[4,3-b]pyridazin-6-yl]phenyl]acetamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-Methylhydrazinecarbothioamide | HCID 2723853 | — |
| 反応物 | N-Methyl-N-[3-(6-chloro-3-pyridazinyl)phenyl]acetamide | HCID 15595702 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | N-Methyl-N-[3-[3-(methylamino)-1,2,4-triazolo[4,3-b]pyridazin-6-yl]phenyl]acetamide | HCID 15595689 | 30.9% |
反応手順
A solution of 6.0 g N-methyl-N-[3-(6-chloro-3-pyridazinyl)phenyl]acetamide and 4.8 g 4-methylthiosemicarbazide in 200 ml ethanol was refluxed for 5 hours and treated in similar fashion in Example 67. Chromatography on silica gel with dichloromethane-methanol (96:4) and recrystalization from dichloromethane-hexane afforded 2.1 g yellow crystals, mp 213°-215° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04767765 |
| 出典データセット | uspto-grants-1988_08 |
| ORD ID | ord-068f8c38ae0d447b911a6b90870572bf |
| 出典メモ | uspto-grants-1988_08 |