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N-Methylhydrazinecarbothioamide → N-Methyl-N-[3-[3-(methylamino)-1,2,4-triazolo[4,3-b]-pyridazin-6-yl]phenyl]propanamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-Methylhydrazinecarbothioamide | HCID 2723853 | — |
| 反応物 | N-methyl-N-[3-(6-chloro-3-pyridazinyl)phenyl]propanamide | HCID 14280298 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | N-Methyl-N-[3-[3-(methylamino)-1,2,4-triazolo[4,3-b]-pyridazin-6-yl]phenyl]propanamide | HCID 15595694 | 16% |
反応手順
A solution of 5.0 g of N-methyl-N-[3-(6-chloro-3-pyridazinyl)phenyl]propanamide and 3.8 g 4-methylthiosemicarbazide in 200 ml ethanol was refluxed for 18 hours. The mixture was then treated and the product chromatographed as described in Example 70. Recrystalization of the product from dichloromethane-hexane afforded 0.9 g yellow powder, mp 212°-213° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04767765 |
| 出典データセット | uspto-grants-1988_08 |
| ORD ID | ord-689457526f1141bbb582c037084d05f4 |
| 出典メモ | uspto-grants-1988_08 |