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N-Methylhydrazinecarbothioamide → N-Ethyl-N-[3-[3-(methylamino)-1,2,4-triazolo[4,3-b]pyridazin-6-yl]phenyl]-propanamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-Methylhydrazinecarbothioamide | HCID 2723853 | — |
| 反応物 | N-ethyl-N-[3-(6-chloro-3-pyridazinyl)phenyl]propanamide | HCID 14280299 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | N-Ethyl-N-[3-[3-(methylamino)-1,2,4-triazolo[4,3-b]pyridazin-6-yl]phenyl]-propanamide | HCID 15595697 | 8.9% |
反応手順
A solution of 5.0 g N-ethyl-N[3-(6-chloro-3-pyridazinyl)phenyl]propanamide and 3.8 g of 4-methylthiosemicarbazide in 200 ml ethanol was refluxed for 18 hours. The mixture was then treated and the product chromatographed as described for Example 70. Recrystallization of the product from acetone-hexane afforded 0.5 g orange crystals, mp 172°-173° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04767765 |
| 出典データセット | uspto-grants-1988_08 |
| ORD ID | ord-58dcf99801004d4eb418f083e5e24d1a |
| 出典メモ | uspto-grants-1988_08 |