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Water → 3-[[3-(Hexadecyloxy)-2-methoxypropoxy]methyl]benzenemethanol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | 1-O-hexadecyl-2-O-methylglycerol | HCID 1380 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 1,3-Benzenedimethanol | HCID 69374 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 3-[[3-(Hexadecyloxy)-2-methoxypropoxy]methyl]benzenemethanol | HCID 19939554 | — |
反応手順
To a suspension of 2.8 g of sodium hydride in 25 ml of dimethylformamide was added at 0° C. over 30 minutes a solution of 1,3-benzenedimethanol in 75 ml of dimethylformamide. After 30 minutes a solution of 3-(hexadecyloxy)-2methoxy-1-propanol, 4-methyl benzene sulfonate in 25 ml of dimethylformamide was added over 30 minutes. After stirring 18 hours the mixture was poured into water and extracted with ethylacetate. The solution was dried and the product was purified by chromatography giving 4.7 g.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05411983 |
| 出典データセット | uspto-grants-1995_05 |
| ORD ID | ord-b803c018fdff491c8fff6b3c2b716dd8 |
| 出典メモ | uspto-grants-1995_05 |