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Pyridine → 3-(Bromomethyl)benzoic acid, 3-(hexadecyloxy)-2-methoxypropyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pyridine | HCID 1049 | — |
| 反応物 | 1-O-hexadecyl-2-O-methylglycerol | HCID 1380 | — |
| 反応物 | 3-(Bromomethyl)benzoyl chloride | HCID 14471076 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 3-(Bromomethyl)benzoic acid, 3-(hexadecyloxy)-2-methoxypropyl ester | HCID 57087588 | 78.3% |
反応手順
a mixture of 8 g of 3-(hexadecyloxy)-2-methoxypropanol, 6.22 g of m-bromomethylbenzoyl chloride, 2.11 g of pyridine and 80 ml of tetrahydrofuran was stirred for 48 hours, then filtered and evaporated. The residue was purified by chromatography and crystallized giving 10 g of 3-(bromomethyl)benzoic acid, 3-(hexadecyloxy)-2-methoxypropyl ester as white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05411983 |
| 出典データセット | uspto-grants-1995_05 |
| ORD ID | ord-e5e0c058700b43d692f14a2aadf27ffa |
| 出典メモ | uspto-grants-1995_05 |