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Indole-3-pyruvic acid → HCID 54134943、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Indole-3-pyruvic acid | HCID 803 | — |
| 反応物 | Cyclohexylamine | HCID 7965 | — |
| 反応物 | 4-Methylmorpholine | HCID 7972 | — |
| 反応物 | 1-Hydroxybenzotriazole | HCID 75771 | — |
| 反応物 | Dimethylazanide | HCID 182180 | — |
| 溶媒 | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| 生成物 | HCID 54134943 | HCID 54134943 | — |
反応手順
The same method as described in Example 7 was followed for the preparation of N,N-dimethylamide. 500 mg 3-indolepyruvic acid were reacted with 400 ml HOBt and 570 ml EDC.HCl. 340 microliters of freshly distilled cyclohexylamine and 325 microliters NMM were added to the solution, which was reacted for 5 hours.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05002963 |
| 出典データセット | uspto-grants-1991_03 |
| ORD ID | ord-ab4f0216453f46f89472cb195305881f |
| 出典メモ | uspto-grants-1991_03 |