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4-Hydroxy-3-nitrobenzoic acid → Isopropyl Acetate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Hydroxy-3-nitrobenzoic acid | HCID 12033 | — |
| 反応物 | 5-(5-Bromopentyl)-3-methylisoxazole | HCID 13544046 | — |
| 反応物 | 3-bromo-4-hydroxy-N-(2-hydroxyethyl)-5-nitrobenzamide | HCID 20064086 | — |
| 反応物 | Methanol isopropylacetate | HCID 22498805 | — |
| 反応物 | 2-Bromo-4-(4,5-dihydro-2-oxazolyl)-6-nitrophenol | HCID 135621460 | — |
| 生成物 | Isopropyl Acetate | HCID 7915 | — |
| 生成物 | 3-Bromo-4-hydroxy-5-nitrobenzoic acid | HCID 20064066 | — |
反応手順
Intermediates: 5-(5-bromopentyl)-3-methylisoxazole and 2-bromo-4-(4,5-dihydro-2-oxazolyl)-6-nitrophenol. The latter, a bright yellow solid, was prepared by cyclization of 3-bromo-4-hydroxy-N-(2-hydroxyethyl)-5-nitrobenzamide, yellow solid, m.p. 163°-164° C. (from methanol-isopropyl acetate). The latter was in turn prepared by bromination of 4-hydroxy-3-nitrobenzoic acid to form 5-bromo-4-hydroxy-3-nitrobenzoic acid, m.p. 233°-234° C. (yellow solid from isopropyl acetate), esterification to the corresponding methyl ester, m.p. 128°-130° C. (yellow solid from carbon tetrachloride) and reaction of the latter with 2-hydroxyethylamine.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05002960 |
| 出典データセット | uspto-grants-1991_03 |
| ORD ID | ord-3479337427864f90ac8b4c6a0f3f1f5b |
| 出典メモ | uspto-grants-1991_03 |