Methyl 2-bromo-3-methylbutanoate → HCID 19939511、化合物

関与物質

反応手順

The alkylation of 5-n-butyl-2,4-dihydro-4-[[2'-(N-trityltetrazol-5-yl)biphenyl-4-yl]methyl]-3H-1,2,4-triazol-3-one (from Example 2, Step D) with methyl 2-bromo-3-methylbutyrate was carried out as described in Example 3, Step A, except that only 5 equivalents of the alkylating agent was used. After work-up, the residue was flash chromatographed over silica gel (50 mL for 0.324 mmole, eluted using 0.5% MeOH/CH2Cl2) to give the desired material as a white foam in 56% yield, homogeneous by TLC in 5% MeOH/CH2Cl2.

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