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(2-Nitrophenyl)hydrazine → 5-Cyclopropyl-2,4-dihydro-2-(2-nitrophenyl)-3H-1,2,4-triazol-3-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (2-Nitrophenyl)hydrazine | HCID 3314739 | — |
| 反応物 | ethyl N-(carbethoxy)cyclopropanecarboximidate | HCID 54370041 | — |
| 溶媒 | Dichloromethane methanol | HCID 21226129 | — |
| 生成物 | 5-Cyclopropyl-2,4-dihydro-2-(2-nitrophenyl)-3H-1,2,4-triazol-3-one | HCID 135720084 | 69% |
反応手順
By the procedure of Example 4, Step C, 2-nitrophenylhydrazine was reacted with ethyl N-(carbethoxy)cyclopropanecarboximidate. After work-up, the residue was purified by flash chromatography on silica gel (150 mL for 2.0 mmole, eluted with 1.5% MeOH/CH2Cl2) to give the desired material as a yellow foam in 69% yield, homogeneous by TLC in 5% MeOH/CH2Cl2, mass spectrum (FAB) m/e 247 (M+1)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05411980 |
| 出典データセット | uspto-grants-1995_05 |
| ORD ID | ord-bba17d0917914d9fb6f8e3e9787e2847 |
| 出典メモ | uspto-grants-1995_05 |