化工社化工社 化学情報印刷レポート · 研究参考用
Triethylamine → 1-Benzyl-3-(2-chloroethylamino)pyrrolidine-2,5-dione
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Benzylmaleimide | HCID 74204 | — |
| 反応物 | 2-Chloroethylamine hydrochloride | HCID 9793737 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | 1-Benzyl-3-(2-chloroethylamino)pyrrolidine-2,5-dione | HCID 15070002 | — |
反応手順
74.8 g (0.4 mol) of N-benzylmaleimide are reacted with 58 g (0.5 mol) of 2-chloroethylamine hydrochloride and 50.5 g (0.5 mol) of triethylamine in accordance with the working instructions of Example Ia. After working up by chromatography, 81.6 g (77% of theory) of an oil with an RF value of 0.24 (on silica gel using ethyl acetate: petroleum ether=1:1) are obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05416096 |
| 出典データセット | uspto-grants-1995_05 |
| ORD ID | ord-19edba96f9eb4e4584b367e7c511598e |
| 出典メモ | uspto-grants-1995_05 |