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Piperidine → Phenylmethyl alpha-[[[2-(diethylamino)ethyl]thio]methyl]benzenepropanoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Piperidine | HCID 8082 | — |
| 反応物 | Ethanethiol, 2-(diethylamino)-, hydrochloride (1:1) | HCID 16031 | — |
| 反応物 | Benzyltrimethylammonium hydroxide | HCID 66854 | — |
| 反応物 | Benzyl 2-Benzylacrylate | HCID 10912012 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | Phenylmethyl alpha-[[[2-(diethylamino)ethyl]thio]methyl]benzenepropanoate | HCID 19937709 | — |
反応手順
The oil prepared in Step 10 (1.5 g, 5.95 mmol) is dissolved under argon in methanol (22 mL). To this solution is added 2-diethylaminoethanethiol hydrochloride (1 g, 5.95 mmol), piperidine (0.78 mL, 7.85 mmol) and benzyltrimethylammonium hydroxide (0.25 mL, 0.6 mmol), and the mixture is stirred at room temperature for 16 hours. The solvent is removed on a rotary evaporator and then the residue is purified by flash chromotography on silica gel to give the pure title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05416119 |
| 出典データセット | uspto-grants-1995_05 |
| ORD ID | ord-f0be70e54984436190edaae29acd41ab |
| 出典メモ | uspto-grants-1995_05 |